Here is a really good example of taking advantage of your read when you have nothing.
PokerStars $3/$6PL, 9-handed
*** HOLE CARDS ***
MP raises $12 to $18
Fuel55 calls $18 from CO with [5h 5d]
*** FLOP *** [6c 6d 7c]
MP bets $24
Fuel55 raises $30 to $54 (I raise a little here to see if he has a pair or two overs)
MP calls $30 (Looks like a pair)
*** TURN *** [6c 6d 7c] [8s]
MP bets $46
Fuel55 calls $46 (The 8 opens up a lot of possibilities so I make the call getting more than 4:1)
*** RIVER *** [6c 6d 7c 8s] [7h]
MP checks (total scare card)
Fuel55 bets $116
Fuel55 collected $242 from pot
Fuel55 doesn't show hand
My hand is totally counterfeited on the river and I am reduced to playing the board. My opponent checks the scare card on the river since the board now shows two pair and it is entirely possible that I raised him on the flop with a 6 or a 7. I MUST BET or I will lose the pot. If my read that he has an overpair is correct, he really has to fold, which he does.
Make sure you always have the stones to make this river bet, especially in position.